The post Free the Vaccine for Covid-19 appeared first on P2P Foundation.
]]>Around the globe we are taking rapid, drastic action to slow the spread of COVID-19. As we come to terms with the daunting path forward, it’s hard to imagine the day we read the headline “COVID-19 Immunizations Begin.” But our experience with our amazing global scientific community teaches us that it’s only a matter of time until we have a vaccine for COVID-19. This day will arrive. And in that there is hope.
But when we do have a vaccine, will everyone have access to it? Herd immunity only works if the vast majority of the herd is immune. Without affordable access for everyone, across the globe, the vaccine can’t really do it’s job. Already governments around the world are investing billions in tax-payer funds into the research and development of diagnostic tools, treatments, and a vaccine for Covid-19. Since SARS outbreak, the National Institutes of Health alone has spent nearly $700 million on coronavirus research and development. This virus is now a global pandemic, yet experience tells us once the vaccine is discovered, pharmaceutical corporations will want us to pay again to acquire it. How do we make sure pharmaceutical companies profits don’t interfere with doctors, public health officials, and our access to tests, treatments, and the vaccine? How do we make this life saving medicine accessible to our family and friends around the globe and reduce infection?
The good news is that we know what needs to be done, and we – you! – have done it before. We have to fight for free access for all with creative, collaborative and convincing campaigns.
Join us as we do the work, together, to make sure this vaccine does all the good it can do. We won’t win through old methods – holding up signs at a traditional crowded protest march is not an option. So together we’ll find new, better ways that work in our current context. We’ll achieve this by creating an advocacy innovation lab with teams around the world crowdsourcing new methods to achieve our objectives. These “Salk Teams” will design and test creative methods to pressure governments and pharmaceutical corporations to ensure publicly-funded diagnostic tools, treatment, and the COVID-19 vaccine will be sustainably priced, available to all and free at the point of delivery.
Once part of a Salk Team, you’ll connect with dozens of interested, talented and committed people from around the world! You’ll get advanced training through weekly online courses with:
Together with other SALK Team members, you will create experimental actions to move the needle on affordable vaccines.
We hope to learn how to make the COVID-19 vaccine accessible for all. No one knows how to do that, yet, because we can’t do that without going through an innovation process. Within a few months we’ll have created and evaluated the effectiveness of dozens, maybe hundreds, of ideas. Those successes will move forward, developing and evolving into practical methods. We’ll then implement those methods to take huge steps forward in advocacy for access to medicines. Through sharing our work, it will have already reached other regions and inspired new action. There’s no way to innovate on advocacy without a massive amount of experimentation. We hope to learn from those experiments while developing and building a grassroots movement ready to implement them.
We offered two, live online information sessions on Friday, MARCH 27. You can view one here:
Help make this happen.
We understand not everyone is able to participate in the same ways. Your donations will help get this program up an running; building infrastructure, materials for producing actions around the world, and creating, translating, and distributing teaching materials.
Our initial round has begun with roughly 300 participants from 27 countries! If you are interested in the campaign, sign up here to get on the Free the Vaccine newsletter. We’ll send you updates and opportunities to participate.
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]]>The post Pooling Knowledge: Private Medicine vs. Public Health? appeared first on P2P Foundation.
]]>COVID-19 is a global health crisis that demands an immediate global response. But this crisis also lays bare many other crises in our societies. In many Western countries, the response to the virus has shown the vulnerabilities in our public health systems and other essential sectors of society. One major issue that the coronavirus exposes is the dire state of our biomedical system and the role that pharmaceutical companies play in that system.
More and more people have now come to realise that the global race to find a cure for Covid-19 and a vaccine is slowed down considerably by the fact that the system we have now runs on market incentives and patent monopolies. Instead of shielding essential knowledge, companies could work together, share research results and new insights.
The pharmaceutical industry is driven by profit and guided by shareholders. The research and innovation that is needed to come up with cures and treatments is monopolised. A system of patents and licenses is fine-tuned to produce the maximum wealth for a few multi-billion euro corporations. This is how we have organised the world of medicines today. Our system is not driven by public health needs but by profit and the only logic that counts is that of capitalism.
Our system is not driven by public health needs but by profit and the only logic that counts is that of capitalism
This model is based on the belief that the flow of biomedical knowledge should be privatized and protected through intellectual property rights in order to stimulate innovation. This monopoly model gives pharmaceutical companies the freedom to charge as much as they can get away with. It also stifles innovation where we most need it, like in the area of infectious diseases, because there is no money to be made. And finally, this system makes us, the people, pay three times: once to fund the universities and research facilities that create a lot of the knowledge needed for pharmaceutical innovation, once to pay these companies to produce and distribute, and once to our governments to fund our health care system.
It’s hard to estimate how many medicines are not invented, how much talent is wasted and how many people have to suffer because of what not is being researched and developed. This sytem limits the ability to collaborate, share knowledge and build on each other’s work. The public good of scientific medical knowledge and health related technologies has been transformed into a highly protected, privatized commodity.
The COVID-19 crisis marks a critical moment for generating the change we need. But how do we go from this neoliberal capitalist logic to something else, towards a system that is driven by the needs of the public and the health of the people?
The proposal to build a global knowledge pool for rights on data, knowledge and technologies that was presented by Costa Rica is a great example of a step in the right direction, towards transformational change. On March 23rd, the government of Costa Rica sent a letter to the World Health Organization, calling for a Global Covid-19 Knowledge Pool1. In his letter to the WHO, the president of Costa Rica demands a global program to “pool rights to technologies that are useful for the detection, prevention, control and treatment of the COVID-19 pandemic.” It now also enjoys the support of the WHO as well as from the UK parliament and the Dutch government and civil society, which has announced their support the idea of a COVID-19 pool as well.
As mentioned above, under our current system the privatization of knowledge limits the ability to collaborate, share knowledge and build on each other’s work. This really is artificial because knowledge is by nature abundant and shareable. Hence the current handling of medical technologies not only limits access to the ensuing treatments, it also limits innovation.
The Covid-19 Poll would pool relevant knowledge & data to combat Covid-19, creating a global knowledge commons2. It is a proposal to create a pool of rights to tests, medicines and vaccines with free access or licensing on reasonable and affordable terms for all countries. This would allow for a collaborative endeavor, and could accelerate innovation. It would be global, open and offer non discriminatory licenses to all relevant technologies and rights. As such the pool would offer both innovation and access.
Inputs could come from governments, as well as from universities, private companies and charities. This could be done on a voluntary basis but not only. Public institutions around the world are investing massively in Covid-19 technologies and all results could be automatically shared with this pool, meaning this could be a condition attached to public financing.
So, placing knowledge in a commons does not just mean sharing data and knowledge without regard for their social use, access and preservation. It means introducing a set of democratic rules and limits to assure equitable and sustainable sharing for health-related resources. As such it allows for equitable access, collaborative innovation and democratic governance of knowledge. At the same time knowledge commons could facilitate open global research and local production adapted to local context.
Placing knowledge in a commons does not just mean sharing data and knowledge without regard for their social use, access and preservation. It means introducing a set of democratic rules and limits to assure equitable and sustainable sharing
If we consider the COVID-19 pool holistic initiative that treats the knowledge as a commons, not only to accelerate innovation but also recognizing this knowledge as a public good for humanity which should be managed in a way to ensure affordable access for all, it could be transformational. In contrast to the existing Medicines Patent Pool this pool would be global and not primarily focus on providing access to exitisting technologies, but more also on innovation: developing diagnostics, medicines and vaccines.
Instead of proposing tweaks it is now time to challenge the idea of handling medicines principally as a commodity or product, and to propose structural changes in order to approach health as a common good. This means referring to our collective responsibility for – and the governance of health when reframing biomedical knowledge production. Instead of leaving it entirely to markets and monopoly based business models.
For this we should move to an approach based on knowledge sharing, cooperation, stewardship, participation and social equity – in practice, this means shifting to a public interest biomedical system based on knowledge commons and open source research, open access, alternative incentives and a greater role for the public sector. Knowledge pools are a crucial piece of the puzzle.
The current COVID-19 pandemic demonstrates how it is possible to make transformational changes overnight when acting in times of an emergency. Let us use this crisis to acknowledge the failures of today’s biomedical research model and usher in the systemic change needed. The world after Corona will require the consideration of alternative paradigms – it is indeed, as Costa Rica, Tedros and now the Netherlands as well rightfully confirmed – time for the knowledge commons to flourish now.
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]]>The post Human waste: the latest enclosure of the commons? appeared first on P2P Foundation.
]]>First, a little background (from an excellent NYT article on the topic). OpenBiome is a Cambridge, Massachusetts stool bank that provides people with bottles of a “mud-colored slurry” used in fecal transplants. In recent years, physicians have made the amazing discovery that transferring the microbiota of healthy donors into the guts of people with certain illnesses can rescue them from death’s door and cure them. OpenBiome assists in this process by collecting stool donations from the public, processing them in safe and reliable ways, and making them available to patients and doctors for F.M.T., or fecal microbiota transplantation.
Tens of thousands of people suffer from the bacterial infection Clostridiodes difficile, or C. diff, for example. Fecal transplants have proven to be effective in 80% of these patients. Some feel much better within hours. Working as a nonprofit, OpenBiome helps such people by producing between 900 and 1,000 fecal transplant treatments each month, for about $800 apiece.
But now many pharmaceutical companies see fecal transplants as the Next Big Thing: a new way to deliver their drugs to treat diabetes, cancer, obesity, autism ulcerative colitis, and Alzheimer’s and Parkinson’s diseases. As the Times put it, “Human feces, it turns out, are a potential gold mine, for both medical researchers and drug makers.”
Based on the huge success of fecal transplants for C. diff, drug companies would love to extend and control this drug-delivery system for other diseases. Naturally, this would mean pharmaceutical companies destroying the fecal transplant commons and creating a new market order that they could dominate.
Ah, but how to achieve this goal? Answer: Through the strategic use of government regulation.
If the Food and Drug Administration can be persuaded to classify fecal transplants as a “drug” (rather than as organs, tissues, or blood, or some entirely new category), then FDA regulations would greatly favor drug companies and markets as the way to provide fecal transplants. The US Government would in effect create a regulated market for feces, to the exclusion of other potentially reliable, safe, and affordable options, such as commons.
Naturally, policymakers are not likely to regard a fecal commons of the sort facilitated by OpenBiome as the preferred option. Pharmaceutical companies don’t like that kind of competition, and Big Pharma calls the shots in Washington. In the name of rigorous health and safety, federal regulation is likely to be invoked by industry as the most effective way to invent a new market for itself. This would eclipse OpenBiome and preempt the idea of a viable fecal commons.
The drug industry would surely find this option attractive because it is currently having trouble getting patients to participate in clinical trials for fecal transplants – a necessary step for getting FDA approval. Sidelining OpenBiome could only help. The FDA has already stepped up its oversight of OpenBiome, which has caused its prices for fecal treatments to double to $1,600. It doesn’t take much imagination to see how prices would soar much higher — and OpenBiome would suffer — if Big Pharma truly got its claws into this market, selling our own excrement back to us as branded product.
In short, we may be about to witness an historic moment — the market enclosure of human excrement as a medical treatment. Or as one gastroenterologist put it, the rise of the “poop drug cartel.”
Such enclosures are a familiar pattern of capitalism. To meet an important need, commoners demonstrate the feasibility of an innovation through their hard work and mutual aid. Then for-profit businesses swoop in to monetize, privatize, and marketize everything. Commoners lose control of what is theirs, pay more for what they used to get for free or inexpensively, and suffer under the extractive terms of a market order, with the blessings of industry-friendly regulation.
Another path is feasible, but will the FDA make it illegal?
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]]>The post From Lab to Commons: Shifting to a Biomedical System that’s in the Public Interest appeared first on P2P Foundation.
]]>Today Commons Network publishes a new policy paper that takes on the pharmaceutical system and presents real alternatives, based on open source research and the knowledge commons. Commons Network proposes a new vision for the biomedical research system that safeguards universal access to affordable medicines and scientific advances.
Taking the commons perspective allows us to offer a diagnostic of our biomedical innovation system and to put forth a political programme for a transition to a new public interest model. The EU’s market-dominated pharmaceutical policies are sized up from the ‘outside the box’ viewpoint of the common good.
This paper responds to the questions: How does the present pharma model work in Europe, what is wrong with it and what can be done right now to change it. This includes a comparison between the existing model, positive transitions and the transformative commons model with practical examples, principles and outcomes.
The paper also describes a broken pharmaceutical system, that in its current form prevents millions of people in Europe and around the world from getting the medicines they need. It goes on to show how ‘Big Pharma’ creates artificial scarcity by enclosing scientific knowledge resources which could easily be abundant and universally accessible.
The skyrocketing prices of medicines and the lack of affordable access to treatments are key traits of our pharmaceutical system. We are told there are no alternatives. This is not the case. There are alternatives to the current broken pharmaceutical innovation system that do not thrive on high prices nor the privatization of knowledge. Some of these alternatives are already in place on a small scale. Yet policy will have to support a transformation of the entire system for it to be sustainable, efficient and just.
The of medical treatments and knowledge based on patent monopolies, regulatory capture and unfair trade rules means a ‘tragedy of the anti-commons’ where over-medication and under-treatment are two sides of the same coin.
The solution to this conundrum of problems is to unleash the potential of the commons. In short: let’s commonify health-care treatments. We have to unlock the gates around medical knowledge and allow it to be governed democratically both by scientists and citizens as a whole.
This new paper by Commons Network presents the commons approach to biomedical innovation at a time when a new comprehensive approach is so direly needed. The biomedical commons represents a paradigm based on the sharing of knowledge, cooperation, stewardship, participation and social equity.
You can download the summary here,
Or you can read the entire paper embedded in Commons Network’s website.
For more information or collaborations please contact Sophie Bloemen at [email protected] or [email protected]
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]]>The post How Biohackers at Counter Culture Labs Are Trying to Make Insulin More Affordable appeared first on P2P Foundation.
]]>Ruby Irene Pratka: According to the World Health Organization, more than 420 million people around the world — including over 29 million Americans — have diabetes. People with diabetes are unable to naturally produce sufficient insulin, a hormone that regulates blood sugar in the body. Over 90 years ago, Canadian scientists discovered a way to extract the hormone from pigs and cattle and purify it for human use. Then, in the 1970s, scientists used a new “recombitant DNA rechnology” using human genes and bacteria to make insulin.
Problem solved, right? Wrong, say increasing number of doctors in the U.S. Insulin is one of fewer and fewer drugs for which no generic version is available. According to an NPR report from 2015, as these more expensive, new drugs became available, the older ones left the market. The bill for uninsured patients can be several hundred dollars per month — as a result, one Baltimore doctor told NPR that some of his patients had stopped taking the drug altogether, putting their health at risk.
Anthony DiFranco and his team at Oakland’s Counter Culture Labs are hoping to change that. DiFranco is a medical researcher, self-described bio-hacker, and cofounder of the Open Insulin Project. He has Type 1 diabetes himself. DiFranco and his team are working on a protocol to extract insulin from genetically engineered yeast cells and produce a generic drug at a cost of around $10 for a month’s supply. He says users could even eventually produce the drug in their homes. The project has created a definite buzz, raising nearly $17,000 in a crowdfunding campaign on the science-oriented crowdfunding platform Experiment.
Shareable caught up with DiFranco to learn more about the Open Insulin Project and the team’s mission to make diabetes management affordable.
Ruby Irene Pratka: How long have you been involved with the biohacking movement?
Anthony Di Franco: I got involved first in about 2011, with the founding of Counter Culture Labs. A year before that, I had worked on the founding of our sister hacker space, which deals with computer technology, and I wanted to explore ideas related to diabetes. A friend of mine had been doing research on the security of insulin pumps, and I originally wanted to [build] a DIY secure pump, but then people started thinking about founding a biohacking space, and I started rethinking my original idea.
Why insulin?
At the time, I had already had diabetes for five years. I had seen that progress was essentially non-existent — now it’s been 12 years and that hasn’t really changed. One major vendor did release a more secure [insulin] pump, but that was because hackers had pulled ahead and were putting pressure on them. If you want anything done you have to do it yourself. While I was looking into that, I saw a blog post on do-it-yourself thyroid hormones and met with a researcher who was able to get me up to speed on the chemical aspects of making [hormones] manually and potentially automating the process further down the road. We had a successful crowdfunding campaign and started actual lab work in January 2016.
Considering that close to 30 million people in the US alone live with this disease, you would think someone would have tried this before now. Why haven’t they?
I can only speculate on the reason, but it’s undoubtedly a lot of work. Many people seem to be afraid of having to deal with regulatory requirements that cost big companies millions. Insulin is one of the last holdouts where there is no generic version of the drug after more than 90 years. There are low-cost producers in other countries, but Western producers are very good at holding onto the [domestic] market. In some cases, drug companies have paid generic manufacturers not to produce drugs. The big producers are determined to keep their oligopoly.
Chemically, what is insulin? What are you building in the lab?
It’s a very small protein. In the lab, you need to introduce a gene into some organism so it creates the protein, and then find some way to extract it. We started with a protocol to make it in E. coli bacteria, but bacteria lack the sophistication to modify or secrete proteins, so the protein we extract is proinsulin, which still needs to be modified into the active form in the lab. We were looking at just making the proinsulin and making small changes to it that would allow us to complete the other steps in vitro… Now that we have some people on board with expertise in yeast engineering, we’re thinking about moving [the production] to yeast. With yeast cells, you can engineer them to secrete insulin, instead of having to extract proinsulin from dead cell debris [as with the bacteria cells]. Then you can purify [the insulin] from yeast, which is a relatively simple task. That’s what we’re focusing on. We’re still just making proinsulin as a first step and working on engineering the yeast to do everything for us. Our final product will be a strain of yeast cells that secretes insulin. Once we succeed, we will share what we come up with and build something that works for the long term.
Why is it so expensive?
Markets are the main reason. It’s not that expensive to produce. For me, a month’s supply would cost about $10 to produce, but I’m paying about $1,000 before insurance and still $75 after insurance. If people were paying $15 for a drug that cost $10 to produce, that would still be a very healthy profit margin.
Tell us a bit about the work that has gone into this.
Most of it was just persistence. Some weeks there was very little to do in the lab and some weeks there was much more. Right now the yeast experts are the ones that are always in the lab, and I’m doing the organizing. It has been a lot of work, and we have had quite a few people coming and going, but it’s important enough to enough people that we always have enough people to keep moving it forward. A lot of our volunteers have just finished school and have the perfect science background, and they see it as doing something cool for a good cause.
What remains to be done to get the yeast-produced insulin into circulation?
We need to compete the yeast engineering, figure out a technique for purifying it and then look at the next step — how to set up a low-cost manufacturing operation and get over all the regulatory hurdles. That would require more money and more organizational sophistication than we have now, but hopefully by then our case will speak for itself and we will be able to prove we have the technology and it is usable. It will not be a for-profit undertaking.
How do you plan to test this?
First we’ll have to verify that we have created insulin, then we’ll use standard techniques to purify it. From a regulatory point of view, if you’re making an existing drug, you just have to demonstrate that you made the right drug, you don’t have to demonstrate its efficacy all over again. We would just have to show that we made the right [chemical] sequence. We may have to do a receptor-binding study but we’re not going to worry about that right now — we will just focus on making a form of insulin that has been in common use.
A lot of the media coverage of your efforts has referred to “home-brewed insulin”— is that accurate? Are people going to be able to cook this up in their homes?
I don’t know if it will be economical to produce it in your home, but it’s not out of the question. At some point, someone will develop a protein-purifying machine which can be distributed to pharmacists or taken out into the developing world. The technology exists but the engineering work still has to be done.
What is your timeline? When do you hope to be able to distribute generic insulin?
Three or four years from now is a realistic timeline, but I hope we can do it a year or two sooner. I’m hoping we’ll have the yeast strain that does all the work soon, and then we’ll raise money to actually produce the product.
How do you react to the wave of support that you’ve gotten via the crowdfunding initiative?
It has been really encouraging. Although some people have dismissed the whole thing as impractical, a lot of other people have seen the value in it.
What motivates you about this experience?
It has confirmed what I know as a person with diabetes. The establishment views and treats diabetes and diabetes patients as a means of making money, and not as a group of people who need to be cured of an ailment. People are desperate for something they can afford. A significant number of the people who supported us have been people with diabetes who couldn’t afford their own insulin. They gave us 25 bucks to see if we could come up an alternative to these oligopolies. You realize how many people are desperate even in the Western world. By making the market competitive for insulin and eliminating these absurd profit margins, we want to contribute to the realignment of incentives in health care. We’re watching people slowly degenerate due to this condition [and] I’m skeptical about whether the economic landscape incentivizes a cure in the short term. If projects like ours give people access to drugs, in the long term they collapse the market and [incentivize] getting a cure out there.
Header photo courtesy of Anthony Di Franco.
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]]>The post “Intellectual Property” Keeps Right On Killing appeared first on P2P Foundation.
]]>Even if it’s true that Roundup is safe if used to company specifications, as Monsanto claims, when is it ever so used? Given the gross power imbalances in the agribusiness industry, nobody’s going to hold giant plantation farmers to account for cutting corners when it comes to their workers’ exposure to toxic chemicals. Back in the 80s, I witnessed the large-scale use of Roundup to “eradicate weeds” on the lawn outside Old Main at the University of Arkansas. In fact it also eradicated the grass and killed some of the oak trees as well. And even as the physical plant workers themselves applied the Roundup in getups that looked like space suits, groups of students clad in shorts and tank tops casually strolled through the clouds of toxic chemicals.
I would also add that it’s disingenuous to give Roundup a pass based entirely on its danger or non-danger to consumers. The effects of Roundup — and the system of large-scale monoculture plantation farming it’s a part of — on farm workers and the ecosystem are also important.
No doubt libertarians will object to labelling requirements at all, including active ingredients. But libertarians also tend to favor a vigorous civil law of torts — or should so favor, if they’re not hypocrites — as a substitute for the regulatory state. And part of tort law is the ability to subpoena evidence relevant to an alleged harm. In a libertarian legal order (stipulating for the moment the unlikely possibility that anything resembling corporate agribusiness could ever have arisen in a free market in the first place), given the prevalence of cancer like non-Hodgkin lymphoma among agricultural workers exposed to Roundup, there would long ago have been lawsuits in which Monsanto was compelled to disclose the full list of ingredients in Roundup. And in any case “trade secrets” guaranteed by law, or enforced by any means other than the actual secrecy of the company itself and non-binding on third parties, would not exist at all.
So the existence of legally protected trade secrets is a weapon against the health and welfare of the public, depriving them of any knowledge of the nature of toxic chemicals they may be exposed to.
This is nothing new. We’ve already seen it in regard to the cocktail of ingredients used in hydraulic fracturing, or “fracking,” which is also kept secret from the potentially affected public by “intellectual property.”
And, in addition to the deaths caused by “intellectual property” itself, the state doesn’t mind, when necessary, inflicting large-scale death in its enforcement of “intellectual property” — as indicated by leaked diplomatic letters from the Colombian embassy (“Leaks Show Senate Aide Threatened Colombia Over Cheap Cancer Drug,” The Intercept, May 14). Colombia has been taking steps towards approving a cheaper generic form of the patented cancer drug imatinib, which costs $15,000 for a year’s supply. An aide to Sen. Orrin Hatch — an intimate friend of the pharmaceutical industry and an ultra-hawk on all “intellectual property” issues — expressed “concern” to Colombian diplomats that if Novartis’s “intellectual property” rights were violated the drug industry might “become very vocal and interfere with other interests that Colombia could have in the United States.” In particular, “this case could jeopardize the approval of the financing of the new initiative ‘Peace Colombia.’” Peace Colombia is an attempt at a negotiated peace settlement between the government and guerrillas, and includes funding for the cleanup of land mines.
So basically Pharma’s Congressional hitmen are willing not only to cause death by denying affordable life-saving medicine. They’re also willing to obstruct (“Nice peace plan you got there…”) an end to a civil war that has killed thousands, and the deactivation of land mines in a country with the second-highest rate of land mine casualties in the world.
“Intellectual property” isn’t just theft. It’s terrorism.
Photo by Artist in doing nothing.
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